Abstract
4-(2,4-Dichloro-5-methoxy)anilino-5,10-dihydropyrimido[4,5-b]quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity. The corresponding 4-(2,4-dichloro-5-methoxy)anilino-pyrimido[4,5-b]quinolines are much less effective Src inhibitors.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Cell Division / drug effects
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Cell Line, Transformed
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Fibroblasts / cytology
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Humans
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Inhibitory Concentration 50
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Quinolines / chemical synthesis*
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Quinolines / pharmacology
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Structure-Activity Relationship
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src-Family Kinases / antagonists & inhibitors*
Substances
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Antineoplastic Agents
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Enzyme Inhibitors
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Quinolines
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src-Family Kinases